"Pentoxifylline": equivalent, manuals, reviews, prices

What can I replace the drug Pentoxifylline? An analogue of this drug will be presented in the article. From it you will learn about what this medicine is intended for, in what forms it goes on sale, how it should be used, and so on.

pentoxifylline analog

Composition, shape, packing

In what form is the medicinal product sold"Pentoxifylline"? Instructions for use (analogues of this drug can be found in any pharmacy) indicates that this medication is issued in different forms, namely:

  • In tablets (400 and 100 mg), which are covered with a shell of pink color. One carton can contain 60 or 20 pieces.
  • In the pills (400 and 100 mg). In one pack of cardboard can be 60 or 20 pieces.
  • In the tablets of prolonged action (600 and 400 mg), which are covered with an enteric coating and have a line for division. In a package of cardboard usually contains 50 pieces.
  • In ampoules with solution for injection. The composition of this drug includes pentoxifylline, as well as sodium chloride and water.

Pharmacological features

What are the properties of the drug Pentoxifylline? The analog of this remedy has the same features as the medication itself. He is referred to a new pharmacological group of hemorheological agents. It is able to restore the plasticity of erythrocytes and reduce their deformation. This increases the permeability of the vessels, which have a narrow lumen.

Such properties of the drug lead to better microcirculation, positively affecting the tissue during hypoxia.

How does Pentoxifylline work? Analogues imported and Russian have the same therapeutic effect as the medication itself. After using the drug, it reduces the aggregation of erythrocytes, which subsequently easily increase the blood supply of organs and enter the extravascular course.

It is impossible not to say that thethe drug reduces the viscosity of the blood, thereby contributing to the disaggregation of platelets. As a result of this exposure, the minute and shock volumes of blood are increased, but the heart rate does not change.

pentoxifylline instruction on the use of analogs

Thus, the expansion of the lung vessels improves the filling of the O2 blood, and the expansion of the coronary arteries increases the delivery of O2 to the myocardium.

The drug in question can increase the tonediaphragm and respiratory musculature. Under its influence, the amount of blood that flows through the collaterals increases, and blood circulation increases in them.

What other features does the medicine have?"Pentoxifylline"? The analogue of this drug and the drug itself increase the concentration of ATP in the brain, and also improve blood supply in the disturbed areas (for example, with ischemic stroke).

It should also be noted that the said medicamentpositively affects the central nervous system and its work. With the defeat of peripheral arteries, the use of this agent leads to an increase in walking distances, including with such a disease as an obliterating endarteritis.

Pharmacokinetic parameters

How long is the drug "Pentoxifylline" absorbed? Instructions for use (analogs of this medication are listed below) informs us that this medication has an excellent penetrating power, including through the blood-brain barrier.

The half-life of the drug with intravenous administration is 30 minutes. When taking the medicine inside, it is completely adsorbed from the digestive tract.

pentoxifylline analogues price

The medicine is transformed in the liver, where heforms metabolites of dimethylxanthine. In the blood, the maximum concentration of the drug is reached within 4 hours after use. At the same time, it remains at the therapeutic level for about a day.

The drug is excreted mainly by the kidneys (about 95%). Through the intestine, the medication goes out insignificantly.

In the fairer sex, who are fedthe baby can be allocated with the milk. It should also be noted that the withdrawal of this drug is slow in patients with severe kidney disease, liver disease and in the elderly.

Indications for use

For what purposes can a patient be prescribed Pentoxifylline medication? Analogues and drug substitutes have the same indications for use.

Currently, such an effective drug is used to treat many diseases. We list them right now:

  • cerebrovascular insufficiency;
  • urolithiasis;
  • atherosclerotic encephalopathy;
  • ischemic stroke;
  • diabetic nephroangiopathy;
  • arterial hypertension;
  • obstructive bronchitis;
  • bronchial asthma;
  • violations of peripheral circulation;
  • encephalopathy;
  • algodismenorea;
    trental analogue of pentoxifylline
  • sepsis;
  • cholecystitis;
  • dyskinesia of the intestine;
  • pilorospasm;
  • spasms of smooth muscles;
  • postthrombophlebitic syndrome;
  • dysmenorrhea;
  • angioneuropathy (Raynaud's disease);
  • disorders of the blood circulation of the eye;
  • violation of trophic tissue;
  • trophic ulcers;
  • threatening miscarriage;
  • functional disorders of the middle and inner ear;
  • vascular impotence;
  • muscular dystrophy;
  • gangrene, frostbite.

Contraindications for use

At what diseases it is forbidden to usethe drug Pentoxifylline? An analogue of this medicine and the drug itself can not be taken to people with intolerance of the main components, as well as other representatives of the xanthine group.

In addition, the drug in questioncontraindicated in patients who have recently suffered a hemorrhagic stroke or acute myocardial infarction, as well as suffering from severe atherosclerosis of the heart and brain arteries, porphyria.

pentoxifylline analogues imported

It is forbidden to use medicament intravenouslywith arrhythmia, bleeding, low blood pressure, hemorrhages in the retina of the eye. Also, the drug is contraindicated in lactating and bearing fruit, children under 18 years.

With special care this tool is prescribedoperated people (to prevent bleeding of the mucous membranes and internal organs), as well as patients with severe form of kidney and liver diseases, with peptic ulcer of the gastrointestinal tract, gastritis and heart failure.

Methods of application

How is Pentoxifylline used? Instructions for use, reviews (analogs of this drug may have other dosages) of experienced doctors say that this medication is taken orally and parenterally (depends on the severity of the disease).

Oral administration of the drug begins with a dose of 200mg (i.e. 2 tablets three times a day, after meals). After achieving the therapeutic effect, the indicated amount is reduced by half. The course of treatment with tablets should last no more than a month.

In severe and acute diseases of internalthe medication is prescribed in ampoules. There are 2 ways of drug administration: intravenous and intra-arterial. The first procedure is carried out by means of a dropper. To do this, use 1 ampoule per 250 ml of glucose solution or sodium chloride. This dosage is administered for 2 hours.

With regard to intra-arterial administration of the drug, it is prescribed in a dose of 0.1 g per 50 ml of sodium chloride solution.

pentoxifylline analogs and drug substitutes

Side effects

Among the most common side effects can be identified as follows:

  • dizziness, anxiety, sleep disturbances, convulsions, mood changes, headache;
  • exacerbation of cholecystitis, increased activity of liver transaminases, development of cholestatic hepatitis;
  • vomiting, a feeling of overflow in the stomach, nausea, diarrhea, decreased appetite;
  • urticaria, anaphylactic shock, itching, angioedema, redness of the facial skin;
  • occurrence of arrhythmia, pain in the heart, lowering blood pressure, anginal pain;
  • thrombocytopenia, leukopenia;
  • accommodation, visual impairment;
  • exacerbation of bronchial asthma, bronchospasm, respiratory failure;
  • bleeding of different etiology.

Preparation "Pentoxifylline": analogues, price

The following drugs are analogues of the medicine in question:

  • Agapurin drops (100 mg), as well as a solution for injections in ampoules (100 mg);
  • tablets "Vasonite", coated with a coating (600 mg);
  • tablets and a solution for injections "Trental".

It should be specially noted that "Trental" is an original drug. It is prescribed to patients with encephalopathies of different origin.

As for the price, all of the listeddrugs it is different. Analog "Trental" "Pentoxifylline" can be purchased for 120 rubles, the original medication - for 520 rubles, "Agapurin" - for 300 rubles, and "Vazonit" - for 400 rubles.

pentoxifylline application instructions reviews analogues

Reviews

Reviews about this drug are mostly positive. The medication is effective in the vascular diseases of many systems and organs. Most reviews on the use of "Pentoxifylline" were abandoned by men who suffer from obliterating endarteritis with intermittent claudication. This medicine is their No. 1 remedy, as this disease has the property of progressing.

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