"Amitriptyline Nycomed" 25 mg: instructions for use, product description, reviews

Stress conditions occur in adultsquite often, but usually they are associated with everyday problems and are eliminated by ordinary rest, a change of scenery or light natural preparations. In cases of more complex depressive situations, doctors can prescribe to the patient "Amitriptyline Nycomed" (25 mg), the instruction for which is described below.

Indications for use

amitriptyline nicomed 25 mg instructions for use
"Amitriptyline Nycomed" (25 mg) indications for use has the following:

  • autism;
  • hypochondria;
  • depression;
  • schizophrenic psychosis;
  • bulimia nervosa;
  • bed-wetting;
  • chronic painful syndromes;
  • ulcerative diseases;
  • prevention of migraine.

Among all the list of serious nervous disordersit should be noted that the drug is prescribed by specialists even for patients with cancer, in order to reduce pain. If the emotional state and behavior are disturbed, anxiety, sleep disturbances and depressed depression worsen, the remedy helps 100%, it is important to remember only that it does not begin to act immediately.

Analogues and cost

"Amitriptyline Nycomed" (25 mg) in tablets in stationary pharmacies costs about 50-70 rubles per package. Also, the drug is available in the form of solutions for injections and infusions.

"Amitriptyline" (25 mg) is produced in tablet form by many companies under the same name.

So, analogues of the drug from the pharmaceutical company "Nycomed" are medicines from the manufacturers:

  • Zentiva;
  • "Grindeks".

Also there is a cheaper variant of domestic production and a tablet called "VERO-AMITRIPTYLIN", produced by many pharmacological foreign companies.

Pharmacology of the drug

"Amitriptyline Nycomed" (25 mg) Descriptioncharacterizes as the strongest antidepressant of the tricyclic group. When a doctor prescribes this drug for use, it is very important to remember that its effect is fully observed only 2-3 weeks after the initiation of therapy.

Decreased depression in patientsis often observed much earlier than the stated time and is caused by increased concentration in the body of norepinephrine. Already after a few days anxiety begins to completely disappear, and after a couple of weeks the psychological state completely stabilizes and agitation disappears. The equilibrium of the nervous system is also restored by the normalization of serotonin and β-adrenergic receptors in the body.

"Amitriptyline Nycomed" (25 mg) instruction onapplication also describes as an effective remedy against severe pain syndromes. Its analgesic effect is also associated with the normalization of the level of serotonin in the body. Also, the drug normalizes the amount of monoamine in the nervous system.

In addition, the product has a pronouncedsedative effect and is able to block acetylcholine in the blood of patients. This often leads to confusion during therapy, dizziness, visual impairment, dry mouth, constipation, or difficulty in urinating. All these effects are indicated in the instructions to the drug as possible side effects. By the way, it is thanks to them that the medication is prescribed as effective at night urinary incontinence, because it is the blocking of acetylcholine that allows the bladder to stretch more, while increasing the tone of the sphincter.

From what tablets "Amitriptyline Nycomed" (25 mg)help more? This list necessarily adds ulcerative diseases of the stomach or duodenum. The effectiveness of the drug in the treatment of these ailments is due to its ability to block histamine receptors and to have a sedative effect. This is what helps patients not only to reduce pain, but also to speed up the healing of ulcers on the mucous surface of internal organs.

Interestingly, the effectiveness of the drug atBulimia is not explained in any way by its pharmacological properties, but it remains obvious. "Amitriptyline Nycomed" (25 mg) helps patients with this diagnosis even without pronounced signs of depression. The mechanism of action is most likely due to the antidepressant properties characteristic of the preparation.

It is important to know that "Amitriptyline Nycomed" (25 mg),the instruction to which is attached in each pack, is able to significantly reduce blood pressure, body temperature and even slow down breathing when the dose is exceeded or during anesthesia. That is why the drug should be discontinued several weeks before the planned operations and be sure to alert specialists about the list of medications used.

Blocking the cleavage of monoamine oxidase does not cause the agent.

Pharmacokinetics of tablets

amitriptyline nicomed 25 mg
Getting into the patient's body, "Amitriptyline" (25mg) binds to plasma proteins by 80-96%, depending on the secondary conditions. Its bioavailability is about 50%, and the half-life is between 30 and 45 hours. Removal of the remnants of the drug is carried out mainly by the kidneys.


"Amitriptyline Nycomed" (25 mg) instruction onuse recommends starting with a minimum dose for all patient categories and regardless of diagnosis. Dosage in this case is prescribed by the attending physician from 25 mg to 50 mg per day at a time before bedtime. Only after application of the drug in this regime, its daily amount gradually increases depending on the disease to a maximum of 200 mg. Most of the recommended amount of the drug is also taken at night.

Only if there is no visible effect on thefor several weeks from the drug "Amitriptyline" the application is allowed to participate with an increase in the daily dose to 300 mg. This happens very rarely and only in special cases.

Immediately after the disappearance of visible signsdepression or other nervous disorders, the dosage of the drug is reduced to a minimum (50-100 mg) and continues treatment until the end of the prescribed course. Usually, therapy with this drug lasts several months. It is important to know that in the elderly due to the risk of side effects of "Amitriptyline Nycomed" (25 mg), the instruction confirms this, should be taken in the active phase with a maximum dosage of 100 mg, and with the disappearance of visible problems - 50 mg and only at night.

Children's urinary incontinence is treated with the drug only from the age of six, since it is forbidden to give it to children before. Dosage in this case is 10-20 mg in children under 10 years and 25-50 mg - up to 16 years.

"Amitriptyline" can be used as an injection for the treatment of various diseases, but contraindications and dosage in this case are calculated completely differently.

Prohibitions to use

amitriptyline nicomed 25 mg instructions
"Amitriptyline Nycomed" (25 mg) contraindications has a lot, because it is characterized as a very strong antidepressant.

In addition to individual intolerance to any of the components of the drug, it is forbidden to use:

  • during gestation and lactation;
  • children under six years;
  • during the recovery period after a heart attack;
  • at a closed angle glaucoma;
  • with severe heart disease;

It is also strictly forbidden to take "Amitriptyline" together, alcohol, psychotropic, analgesic and hypnotics.

Adverse Events

Since "Amitriptyline Nycomed" (25 mg)the instructions for use characterize it as the strongest antidepressant, the list of its possible undesirable effects is very wide. Despite this, according to reviews, most patients do not have them at all or only have dizziness in the first days after the start of therapy.

So, the drug can cause frustration from the side:

  • nervous system;
  • digestive;
  • cardiovascular;
  • endocrine;
  • hematopoietic.

Also, "Amitriptyline", the instruction contains a completelist of side effects, can cause various allergic reactions to the skin in the form of rashes, swelling or itching. In addition, in some patients, hair loss, enlarged lymph nodes and tinnitus were seen in the studies.

Among the most common sideThe patients distinguish characteristic manifestations of anticholinergic activity. They include dizziness, dry mouth, tachycardia, confusion, especially hallucinations.

Less common are disordersdigestive system in the form of nausea, changes in taste, appetite disorders, heartburn, stomatitis, diarrhea. Very rarely in this direction, there are violations of the liver and hepatitis.

From the side of the thyroid gland canthere are breast enlargements in women and a violation of potency in men. The common effect for either sex is a decrease in libido. In the work of the heart, arrhythmias, tachycardias, dizziness, nonspecific indices during an electrocardiogram and so on can manifest.

Particular attention should be given to the list of possiblenegative manifestations on the part of the nervous system. Despite the fact that the drug is aimed specifically at its stabilization, most of the risk of side effects is also associated with it.

So, patients can observe:

  • anxiety;
  • drowsiness;
  • increased depression;
  • fainting;
  • manic states;
  • disorientation;
  • psychosis;
  • headache;
  • insomnia;
  • nightmares in a dream;
  • more frequent epileptic seizures.

Interaction with other medicinal products

amitriptyline 25 mg
It is very important for all patients to remember, even if alreadybefore exhaustion, the depression worsened: "Amitriptyline" can not be taken together with other additional drugs that have a depressing effect on the nervous system. This overdose can lead to respiratory depression and a sharp drop in blood pressure. Also, attention should be paid to all drugs used in parallel with anticholinergic action, which can be increased several times.

Also, the negative influence in the form oftachycardia, cardiac rhythm disturbances, inhibition of metabolism and other undesirable phenomena while taking with other antipsychopathic medicines.

During the first days of parallel therapy togetherwith ethanol in patients will be clearly pronounced its effect. In some cases, this effect persists throughout the course of admission. "Amitriptyline Nycomed" (25 mg), instruction and testimonials of patients testify to this, enhances the effect of other chemicals. Thus, simultaneous administration with antihypertensive drugs can provoke the risk of orthostatic hypotension.

Despite the fact that the medication in question is notrefers to MAO inhibitors, taking it in parallel with similar drugs can be dangerous to health. This combination of active substances can provoke hypertensive crisis in the body.

Certain substances can reducethe effectiveness of amitriptyline, others, on the contrary, increase its concentration in the blood so much that patients can develop a toxic reaction. That's why such a serious drug should be taken only after consulting a specialist. An experienced doctor is always able to prescribe the correct dosage and take into account the interaction of the drug with other medications taken.

Additional recommendations

amitriptyline nycomed 25 mg description
"Amitriptyline" has a very wide listpossible side effects and contraindications, but it can become even wider if you do not take into account certain recommendations. So, take the drug with caution in chronic alcoholism, because with alcohol, the drug in principle is incompatible. In addition, it is necessary to take into account the presence of arrhythmia, arterial hypertension, heart failure or active phase of thyroid therapy during the appointment of the drug in patients.

Patients undergoing therapy with "Amitriptyline",must take into account that the active substance is capable of causing turbidity during a sharp transition to an upright position, so you should always get up smoothly. Also, with a long period of therapy and a sharp cessation of treatment, most people develop withdrawal syndrome.

Since the drug is incompatible with drugs that inhibit MAO, it should be started no earlier than 2 weeks after discontinuation of taking the above funds.

Doctors should always be warned about admissionthis medication, precisely because it is able to influence the action of other medicines. It is also necessary to exclude simultaneous reception with ephedrine, phenylephrine and similar substances.

In elderly patients, especiallyobserving bed rest and little moving, the drug can cause acute intestinal obstruction. Any complex effect on the body in the form of electrotherapy is allowed only under the strict supervision of doctors.

Long-term use of the drug may provoke the appearance of caries and the need for additional consumption of riboflavin.

If the medication is prescribed to the patient in a dailydosage more than 150 mg, that is the probability that the concentration of the substance in the body will provoke a further increase in epileptic seizures and a vivid manifestation of the convulsivity syndrome in other symptoms. With prolonged use, it must also be taken into account that patients may have suicidal tendencies, especially when the drug is abruptly withdrawn.

Application under certain conditions

amitriptyline nicomed 25 mg indications for use
At any age, patients should avoidmanagement of vehicles and complex mechanisms during therapy. The fact is that "Amitriptyline" is able to depress human attention and reduce the speed of its psychomotor reactions.

In childhood, the drug is used onlyfrom the age of 6 years in the form of tablets. There are even greater restrictions on the injection liquid. They can be used for children only from the age of 12 years.

During pregnancy, the drug should be takenIt is forbidden, because, according to the results of the research, it is capable of adversely affecting the development of the fetus. The use of medication is allowed in very rare cases and only in the second trimester, if the benefits completely cover possible harm. It is also necessary to stop therapy on time so that the baby does not develop withdrawal syndrome after birth. The drug should be canceled at least 7 weeks before the expected date of delivery.

During feeding, "Amitriptyline Nycomed" is not used at all, since it can cause drowsiness and addiction in children.

In elderly patients, the drug is oftencauses intestinal obstruction, which should be removed symptomatically or by replacing the drug with another. Also in the elderly, there may be drug psychoses, which most often appear after the drug is discontinued at night.


"Amitriptyline Nycomed" (25 mg) reviews testedpatients collect ambiguous. Most of those who underwent treatment with this medication remained completely satisfied with the result and noted only mild dizziness during therapy. Especially distinguished among the benefits of the drug is a low price, which is available to any person, especially when considering that the course of treatment lasts for several months. In general, even taking into account some of the negative characteristics, absolutely everyone marks its effectiveness. The drug helps patients in a short time to get rid of the strongest mental disorders and bring back the joy of life.

Among the minuses of the tablets, the reviews indicate side effectseffects. Of course, most indicate that over time they pass, but in some cases it is not. If the patient does not cease to pester additional negative manifestations from taking the medication, then it is necessary to consult a doctor, so that he can replace it with another remedy.

Of course, negative reviews are most often metfrom those people who decided to take the medicine themselves, because it is sold without a prescription from a doctor. It is from an incorrectly calculated dose that they have problems. According to reviews from doctors, you can avoid any negative manifestations, correctly taking into account the individual characteristics of the body and the diagnosis of the patient.


amitriptyline alcohol
Many believe that getting a high-qualitya drug, especially against the strongest disorders, is possible only at a sky-high price. "Amitriptyline" completely refutes this statement and helps all patients quickly and effectively cope with any depression for little money. Of course, taking it yourself is not recommended, because an incorrect calculation of the dosage can provoke an intoxication of the body and increase the risk of side effects.

Despite the fact that in the modern world there is aa huge number of different drugs from mental disorders, yet you always need to take care of yourself. Do not load yourself with unnecessary work, whenever possible, try to travel more often, attend cultural events, spend time with your loved ones. Do not forget also about a healthy dream. And only then you will not be afraid of any depression.

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